NCOG-15. A PILOT STUDY ON RETINAL FEATURES AND COGNITIVE FUNCTION IN PATIENTS WITH LOW GRADE GLIOMAS

Abstract BACKGROUND Retinal structure and vascular changes are used as biomarkers for preclinical Alzheimer disease. We conducted a cohort study to evaluate the feasibility of obtaining these data in patients with low-grade gliomas (LGGs) who completed chemoradiation therapy without self or family reported cognitive concerns. METHODS Optical coherence tomography (OCT) angiography (OCTA, OptoVue, Inc.) images were obtained from 6 LGG 2 healthy controls using 4.5 x mm peripapillary 6x6 macular scan patterns. measured OCTA parameters including radial capillary density peri-optic disc region, whole density, foveal avascular zone (FAZ). RESULTS analyzed two eyes control subjects, an patient normal cognition, 5 impairment (mean age 45 years, range 3 months 10 years after chemoradiation). Both had eye exams. Average retinal nerve fiber layer thickness was thinner dysfunction (104 um 106 um, respectively) than (123 um). A similar pattern seen macula (283 290 vs. 325 The average vessel densities lower (47.7% 48.3%, (51.9%). three groups (46.7 %, 48.0%, 48.0 %). FAZs larger (0.254 mm2) cognition (0.204 (0.226 mm2). CONCLUSIONS architecture microvascular by OCT/OCTA is feasible chemoradiation. prospective needed investigate role detecting perifoveal brain tumor treatment-associated dysfunction.